Open AccessTight Junction in Blood‐Brain Barrier: An Overview of Structure, Regulation, and Regulator Substances
Author(s) -
Liu WeiYe,
Wang ZhiBin,
Zhang LiChao,
Wei Xin,
Li Ling
Publication year - 2012
Publication title -
cns neuroscience and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 69
eISSN - 1755-5949
pISSN - 1755-5930
DOI - 10.1111/j.1755-5949.2012.00340.x
Subject(s) - tight junction , paracellular transport , blood–brain barrier , regulator , limiting , neuroscience , central nervous system , claudin , permeability (electromagnetism) , biology , chemistry , microbiology and biotechnology , biochemistry , engineering , gene , mechanical engineering , membrane
SUMMARY Blood‐brain barrier (BBB) is a dynamic interference that regulates the nutrition and toxic substance in and out of the central nervous system (CNS), and plays a crucial role in maintaining a stable circumstance of the CNS. Tight junctions among adjacent cells form the basic structure of BBB to limiting paracellular permeability. In the present review, the constituents of tight junction proteins are depicted in detail, together with the regulation of tight junction under stimulation and in pathological conditions. Tight junction modulators are also discussed.