Open AccessRESEARCH: Zopiclone (Cyclopyrrolone): A Novel Hypnosedative; Hypnosedation Caused by Zopiclone Does Not Impair Memory‐Learning in Albino Mice
Author(s) -
Kadam Uma,
Bhosale Anand
Publication year - 2010
Publication title -
cns neuroscience and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 69
eISSN - 1755-5949
pISSN - 1755-5930
DOI - 10.1111/j.1755-5949.2010.00165.x
Subject(s) - open field , zopiclone , righting reflex , elevated plus maze , sedation , anesthesia , pharmacology , psychology , long term potentiation , hypnotic , reflex , chemistry , medicine , psychiatry , receptor , anxiety
SUMMARY Objectives: To evaluate hypnosedative action of Zopiclone by using animal models for hypnosis and sedation (anxiolysis); and to further evaluate whether this hypnosedation impairs memory‐learning in albino mice like conventional hypnosedatives. Methods: For evaluation of hypnosedation, following experiments were performed in albino mice: (1) righting reflex test, (2) pentobarbitone sleeping time potentiation, (3) open field apparatus behavior, and (4) elevated plus maze performance. For evaluation of effects on impairment of memory‐learning, elevated plus maze retention test was performed in albino mice. Results: Zopiclone (7.5 mg/kg p.o.) did not inhibit the righting reflex. Significant ( P < 0.001) potentiation of pentobarbitone sleeping time and increase in exploration in open field apparatus was observed. Elevated plus maze performance also showed significant ( P < 0.01) increase in number of entries to open arm at the same time significant ( P < 0.02) increase in time spent in open arm was observed. Elevated plus maze retention test showed significant ( P < 0.01) increase in transfer latency on second day of experiment. Conclusions: Zopiclone (7.5 mg/kg p.o.) has selective hypnosedative activity but not CNS‐depressant activity similar to BZDs. Hypnosedative action of Zopiclone does not impair memory‐learning in albino mice like conventional hypnosedatives.