Open AccessRegenerative Therapy in Peripheral Artery Disease
Author(s) -
Germani Antonia,
Di Campli Cristiana,
Pompilio Giulio,
Biglioli Paolo,
Capogrossi Maurizio C.
Publication year - 2009
Publication title -
cardiovascular therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 46
eISSN - 1755-5922
pISSN - 1755-5914
DOI - 10.1111/j.1755-5922.2009.00105.x
Subject(s) - medicine , critical limb ischemia , progenitor cell , stem cell therapy , genetic enhancement , cell therapy , revascularization , percutaneous , peripheral , disease , vascular disease , clinical trial , ischemia , regeneration (biology) , endothelial progenitor cell , stem cell , surgery , arterial disease , transplantation , myocardial infarction , gene , biochemistry , chemistry , biology , genetics , microbiology and biotechnology
Patients with peripheral artery disease (PAD) and critical limb ischemia are the main candidates for limb amputations and have a poor life expectancy. Frequently, these patients are not eligible for either surgical or percutaneous interventions aimed at mechanical revascularization. Therefore, new strategies need to be identified to offer these patients a viable therapeutic option. Gene and cell therapy hold great promise for the treatment of peripheral vascular diseases because, in animal models, local delivery of growth factors and endothelial progenitor cells result in new blood vessel formation and regeneration of ischemic tissues. In this article, are reviewed phase I and phase II gene, and cell therapy clinical trials in patients with PAD.