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Survival analysis of inherited retinoblastoma: a population‐based analysis, 1975–2011
Author(s) -
Yassa Arsany,
Mikhael Sandra,
Tadrosse Abanoob,
Mikhael Mina,
Eloy JeanAnderson
Publication year - 2021
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.20200176
Subject(s) - medicine , retinoblastoma , epidemiology , survival analysis , population , demography , confidence interval , cancer registry , surveillance, epidemiology, and end results , retrospective cohort study , overall survival , oncology , biology , genetics , environmental health , sociology , gene
Purpose To study the survival patterns of inherited Retinoblastoma. Methods A retrospective, population‐based analysis was conducted on children younger than 5 years old using the Surveillance, Epidemiology, and End Results Registry from 1975 to 2011. Bilateral cases (BL) were used as a proxy for inherited ones. Kaplan–Meir analysis was used to calculate 5‐year overall survival (5yOS). Results Four hundred fifty‐three cases were identified. 5yOS was 93.3%. There was no significant difference in 5yOS between sexes (p = 0.72), among white, black and other races (p = 0.17) or among patients diagnosed during the first, second and third years of life (p = 0.453). Survival based on staging was: localized (95.8%), regional (83.7%), distant (91.6%) (p < 0.01). 5yOS during the interval 1975–1990 (87.0%) was significantly lower than during the interval 1996–2011 (95.5%) (p < 0.01). Conclusions Survival of inherited retinoblastoma is not affected by sex, race or age at diagnosis. Staging is a prognostic factor for survival. Survival shows improvement over the timeframe studied. Bibliography Surveillance Research Program, National Cancer Institute SEER*Stat software ( seer.cancer.gov/seerstat ) version 8.3.6.