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Epidemiological analysis of conjunctival lymphoma: a population‐based study, 2000–2016
Author(s) -
Mikhael Sandra,
Tadrosse Abanoob,
Yassa Arsany,
Mikhael Mina,
Eloy JeanAnderson
Publication year - 2021
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2020.0166
Subject(s) - medicine , epidemiology , incidence (geometry) , lymphoma , gastroenterology , population , malt lymphoma , follicular lymphoma , physics , environmental health , optics
Purpose To study epidemiological trends of conjunctival lymphoma. Methods A retrospective, population‐based analysis of patient data extracted from the Surveillance, Epidemiology, and End Results Registry US database was conducted from 2000 to 2016. Incidence (IR) was calculated in number of cases/million/year. Disease‐specific survival (DSS) was calculated using the Kaplan‐Meier method. Results 978 cases of conjunctival lymphoma (CL) were identified, of whom 52% were females and 65% were white. The most common histological subtypes were mucosa‐associated lymphoid tissue (MALT; 70.9%) and follicular lymphoma (11.7%). Diffuse large B‐cell lymphoma constituted only 3.4% of cases. Overall IR of CL was 0.7. Annual percent change showed a significant decline (−1.4) in IR of CL during 2000–2016 (p = 0.02). There was no difference in IR between sexes (p = 0.34). IR in Asian/Pacific Islander patients (0.9) was significantly higher than that in white (0.6) and black (0.5) [p < 0.01] patients. Mean diagnostic age in years was 59.3 [Standard Deviation = 17.9]. IR in patients older than 65 years old (y/o) [2.36] was significantly higher than that in those 22–64 y/o (0.63; p < 0.01) and those younger than 21 y/o (0.06, p < 0.01). IR of unilateral cases (0.6) was significantly higher than that of bilateral ones (0.1) [p < 0.01] and there was no significant difference between left and right laterality (p = 0.72). 5‐year DSS during 2000–2012 was 97.4%. Race and sex did not affect survival. DSS was similar during 2010–2012 (98.5%) and 2000‐02 (94.1%) [p = 0.099]. Conclusions Conjunctival lymphoma incidence is highest in the elderly and Asian/Pacific Islander populations and is not affected by sex. Incidence is decreasing over the timeframe 2000‐2016. Most common histology for CL is MALT. Overall 5‐year DSS for CL is 97.4%, and it is not affected by sex or race. Bibliography Surveillance Research Program, National Cancer Institute SEER*Stat software (seer.cancer.gov/seerstat) version 8.3.6.