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Pharmacokinetics of retinal drug delivery
Author(s) -
Urtti Arto
Publication year - 2019
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2019.8310
Subject(s) - retina , drug delivery , drug , retinal , retinal pigment epithelium , limiting , medicine , inner limiting membrane , ophthalmology , pharmacology , biology , chemistry , neuroscience , mechanical engineering , organic chemistry , engineering
The Sight threatening changes of many ophthalmic diseases are present in the retina. Thus, retina is an important drug target, but it is not an easy tissue for drug delivery. Depending on the route of drug delivery (intravitreal, periocular, systemic) the retinal drug exposure is hampered by various physical barriers (vitreous, inner limiting membrane, retinal pigment epithelium and retinal capillaries) and blood flow factors. In this presentation, delivery aspects are discussed quantitatively utilizing modeling tools and addressing required dosing in different situations. Intravitreal, periocular and systemic routes of drug delivery will be discussed. Furthermore, scaling factors for drug doses between mouse, rabbit and humans are presented.