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Corneal dystrophies as a cause of recurrent erosions
Author(s) -
Lisch Walter
Publication year - 2019
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2019.8251
Subject(s) - dystrophy , medicine , corneal dystrophy , tgfbi , ophthalmology , basement membrane , stromal cell , pathology , cornea , transforming growth factor
Especially in anteriorly located corneal dystrophies, recurrent erosions can be observed and are associated with many different histopathological and genetic etiologies: with microcysts in Meesmann corneal dystrophy ( MECD ) from KRT 3 and KRT 12 mutations, with aberrant epithelial basement membrane in epithelial basement membrane dystrophy ( EBMD ), with gradual scarring from COL 17A1 mutation in epithelial recurrent erosions dystrophy ( ERED ), with distinct deposits in the five epithelial‐stromal TGFBI ‐related corneal dystrophies, and with deposits and epithelial thinning in macular corneal dystrophy ( MCD ) from CHST 6 mutations. Rarely does a secondary form occur in the Fuchs endothelial corneal dystrophy ( FECD ) due to an erosive rupture of an epithelial bleb.