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Potential mechanisms to reverse BRVO related retinal ischemia
Author(s) -
Pournaras Constantin
Publication year - 2019
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2019.8197
Subject(s) - retina , retinal , ischemia , hypoxia (environmental) , nitric oxide , blood flow , oxygenation , arachidonic acid , neuroscience , medicine , biology , chemistry , biochemistry , cardiology , oxygen , organic chemistry , enzyme
During the evolution of ischemic microangiopathies, impairment of structure and function of the retinal neural tissue and endothelium, affect the interaction of these metabolic pathways, leading to a disturbed blood flow regulation. The resulting ischemia, tissue hypoxia and alterations in the blood barrier trigger the formation of macular edema and neovascularization. Close interaction between nitric oxide (NO), lactate, arachidonic acid metabolites, released by the neuronal and glial cells during neural activity and energy‐generating reactions of the retina strive to optimize blood flow according to the metabolic needs of the tissue. Efficient control of the multiple pathways, such as retinal blood flow, tissue oxygenation and metabolic substrate support, aiming at restoring retinal cell metabolic interactions, may be effective in preventing damage occurring during the evolution of ischemic microangiopathies.