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Immunglobulin depositions in different organs in monoclonal gammopathy
Author(s) -
Garderet Laurent
Publication year - 2019
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2019.8155
Subject(s) - monoclonal gammopathy , clone (java method) , monoclonal , gastrointestinal tract , monoclonal antibody , kidney , medicine , pathology , monoclonal gammopathy of undetermined significance , immunology , biology , antibody , dna , genetics
Monoclonal immunoglobulins (heavy and/or light chain) can deposit in various organs. The most prominent targeted organs are the kidney, the nerves, the heart, the liver, the gastrointestinal tract but it could also involve the eyes, the skin and it can interact with the hemostasis proteins. This is at the origin of a new concept called monoclonal gammopathy of clinical significance (MGCS). It is challenging to diagnose and even though the B cell clone may be small, it may be important, in some circumstances, to initiate a hematological treatment.