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ANCA‐associated optic neuropathy
Author(s) -
Kawasaki Aki
Publication year - 2019
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2019.8150
Subject(s) - medicine , vasculitis , granulomatosis with polyangiitis , microscopic polyangiitis , pathology , optic neuropathy , necrotizing vasculitis , autoantibody , dermatology , optic nerve , immunology , disease , ophthalmology , antibody
Antineutrophil autoantibodies (ANCAs) directed against either antiproteinase3 (anti‐PR3) or myeloperoxidase (anti‐MPO) are associated with a small vessel vasculitis in which the characteristic feature is a focal necrotizing damage of capillaries, venules and arterioles. The ANCA‐associated vasculitic syndromes are; granulomatosis with polyangiitis (formerly know as Wegener’s granulomatosis), microscopic polyangiitis, Churg‐Strauss syndrome and idiopathic necrotizing crescentic glomerulonephritis. Ocular and orbital manifestations may be a presenting manifestation of Wegener’s granulomatosis, in particular optic perineuritis. This presentation will review ANCA‐associated optic perineuritis and how it is distinguished from idiopathic optic perineuritis.