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Objective assessment of progressive macular changes in glaucoma
Author(s) -
Normando Eduardo M.
Publication year - 2019
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2019.8122
Subject(s) - glaucoma , nerve fiber layer , ophthalmology , medicine , retinal , retina , biology , neuroscience
The role of OCT macula scans in glaucoma has been extensively investigated. However, to date, only subjective and qualitative analyses can be performed for macula scans in glaucoma. We propose a novel method to objectively assess glaucoma progression based on the Longitudinal Analysis of the Poster Pole (LaPo). Forty eyes were assessed over 3 years. Conventional Posterior Pole (PPole) and Peripapillary RNFL protocol were acquired using Spectralis OCT. Longitudinal measurements of Total Retina (TR), Retinal Nerve Fiber Layer (RNFL) and Ganglion Cells Layer (GCL) thickness were performed. Thickness gradients and Lineal regression analyses were calculated in each eye over time. All data are expressed as mean ± SD. p < 0.01 was considered as significant. Linear regression analysis of individual super pixel showed that LaPo can detect progression significantly earlier than peripapillary RNFL in 90.4% (TR, p < 0.01), 96% (RNFL, p < 0.01) and 83% (GCL, p < 0.01) of eyes. In this study we have shown a novel method for objectively quantify glaucoma progression using the PPole scanning protocol. We suggest that macular thickness changes are a potential biomarker for glaucoma diagnosis and progression. Our methodology could contribute to the early identification of progressing patients and may also have a role in glaucoma surveillance schemes.