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Abnormalities of vision and colour vision in Parkinson's disease
Author(s) -
Weil Rimona
Publication year - 2019
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2019.8112
Subject(s) - dementia , parkinson's disease , disease , contrast (vision) , visual acuity , retinal , medicine , degenerative disease , psychology , neuroscience , audiology , ophthalmology , artificial intelligence , computer science
Often thought of as a movement disorder, Parkinson's disease has prominent non‐motor symptoms. Vision is frequently affected, with deficits in acuity, contrast sensitivity and higher order visual processes, as well as retinal changes. These visual deficits may be predictive of dementia in Parkinson's disease. There is now pressure to define accurate markers that predict dementia, to help stratify clinical trials of disease modifying therapies in Parkinson's’ disease. We have collected visual, cognitive and retinal ( OCT ) data in 112 patients with Parkinson's and 35 age‐matched controls. We assessed risk of dementia using validated risk algorithms. We show that higher risk of dementia is associated with poorer performance in visual tests including in colour vision. We also show that retinal thinning in the ganglion cell and inner plexiform layers is linked with higher risk of dementia. Our findings suggest that visual measures and retinal structure may be useful to predict dementia in Parkinson's disease.