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How does aging influence tear fluid proteomics
Author(s) -
Nättinen Janika
Publication year - 2019
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2019.8066
Subject(s) - proteomics , inflammation , medicine , pathophysiology , immune system , ageing , ophthalmology , bioinformatics , immunology , biology , pathology , biochemistry , gene
Abstract The prevalence of many ophthalmic diseases increases with age. While the clinical characteristics and pathophysiological mechanisms of these diseases are relatively well‐known or extensively studied, the underlying biological systems of normal aging in the ocular surface remain unclear. In order to examine the effects of aging on tear fluid proteomics and ocular surface, tear microcapillary samples were collected preoperatively from 115 subjects and analysed using NanoLC‐TripleTOF mass spectrometer. Bioinformatics analysis revealed several inflammation and immune response‐related proteins, which correlated significantly with increased age. Our results display the effects of normal aging in the ocular surface and identify a group of age‐dependent proteins. Knowledge of the proteins, pathways and upstream regulators discovered in our study can be later implemented in the research of dry eye and other ocular surface diseases, which are associated with increased age.