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Pattern of RGCs loss in toxic optic neuropathies
Author(s) -
Barboni Piero
Publication year - 2019
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2019.8008
Subject(s) - mitochondrial dna , optic nerve , blind spot , retinal , optic neuropathy , central scotoma , biology , ophthalmology , medicine , neuroscience , pathology , genetics , gene
Toxic optic neuropathies are characterized by bilateral visual loss, papillomacular bundle damage, central or centrocecal scotoma and color vision defect. Multifactor causes play important role in disease manifestation, and nutritional and/or genetic defects (such as mitochondrial DNA mutation) could trigger the disease. Toxic optic neuropathies cause defect to mitochondrial metabolism with consequent damage of retinal ganglion cells with higher energy (ATP) demand. The pattern of RGC and RNFL loss follow a specific pattern characterized by preferential involvement of fibers of papillo‐macular bundle anatomical distribution, the typical feature of mitochondrial diseases.