Premium
Pediatric OVCR what’s new?
Author(s) -
BremondGignac Dominique
Publication year - 2019
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2019.8004
Subject(s) - medicine , central retinal vein occlusion , thrombophilia , ophthalmology , fundus (uterus) , glaucoma , macular edema , thrombosis , retinal , surgery , pediatrics
Abstract Central retinal vein occlusion (CRVO) is the second cause of visual loss due to vascular disease after diabetic retinopathy. Its pathogenesis remains unclear but risk factors such as hypertension, glaucoma and age have been recognized. Indeed, CRVO occurs mainly after 50 years, and only 10–15% of patients are under 40 years of age. CRVO has been rarely reported in children, but often associated with a local cause (compressive or inflammatory), or a systemic condition as thrombophilic and hyperviscosity syndromes. The clinical presentation includes visual loss and the fundus shows optic disc edema, tortuous dilated retinal veins, retinal hemorrhages and signs of neovascularization at various levels as in adult cases. In children, the role of genetic variants of thrombophilia in the occurrence of CRVO remains unclear. We report 4 cases of central retinal vein occlusion (CRVO) in healthy children showing combined genetic variant of thrombophilia. Mutation of MTHFR (C677T) and GPIIIa PlA1/A2 seems to demonstrate implication in CRVO in children. In those cases, multidisciplinary consultation staff has to discuss preventive low‐dose aspirin therapy.