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Afro‐Caribbean patients have a lower disc vascular density than European patients: a cross‐sectional study
Author(s) -
Liseth Salazar Quiñones Maria,
Sheng Lim K.,
YuWaiMan Cynthia,
De Antonio Ramirez Alba,
García Feijoo Julián,
Dora Méndez Hernánez Carmen,
Peña Urbina Pilar
Publication year - 2019
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2019.5488
Subject(s) - medicine , glaucoma , ophthalmology , optic disc , visual field , visual field test , intraocular pressure , optic nerve
Purpose To determine if there are racial differences in disc vascular density between Afro‐Caribbean and European patients, and the relationship with disease severity in glaucoma. Design Cross‐sectional study. Participants 50 eyes from 32 Afro‐Caribbean glaucoma patients, 35 eyes from 22 European glaucoma patients, 23 eyes from 14 Afro‐Caribbean normal controls, 24 eyes from 12 European normal controls. Methods All patients underwent a complete ophthalmic examination. Disc vascular density was measured using OCT angiography. We compared the disc vascular density of Optic head nerve and peripapillary between Afro‐Caribbean and European patients in normal controls and glaucoma patients. We evaluate superficial vascular complex and matched the severity of glaucoma between the two groups using mean deviation from Humphrey visual field 24‐2 test. We also performed Spearman correlation between the disc vascular density and mean deviation, visual acuity, intraocular pressures, central corneal thickness and cup‐disc ratio. Main Outcome Measures Disc vascular density. Results Afro‐Caribbean normal controls had a lower mean disc vascular density (42.4 ± 0.8 [SEM]) than European normal controls (46.2 ± 0.2; p < 0.0001). We matched the severity of visual field loss in 32 eyes from Afro‐Caribbean glaucoma patients (MD = 5.97 ± 0.75) and 32 eyes from European glaucoma patients (MD = 4.17 ± 0.73; p = 0.090). Afro‐Caribbean glaucoma patients also had a lower mean disc vascular density (33.26 ± 6.60 [SEM]) than European glaucoma patients (36.68 ± 5.28; p = 0.022). There was a moderate correlation between disc vascular density and mean deviation ( r = −0.70, p < 0.0001) in the Afro‐Caribbean glaucoma patients. We found no correlation between disc vascular density and mean deviation ( r = −0.31, p = 0.070) in the European glaucoma patients. Conclusions Afro‐Caribbean patients have lower disc vascular density than European patients in normal controls but not subgroup mild, moderate or advanced glaucoma.