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Progression patterns of normal‐tension glaucoma groups classified by Hierarchical cluster analysis
Author(s) -
Song Park Hyo,
Woo Kim Eun,
Keum Park Cham,
Choi Wungrak,
Hyun Lee Kwang,
Je Seong Gong,
Yun Kim Chan,
Yeop Lee Sang,
Won Bae Hyoung
Publication year - 2019
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2019.5240
Subject(s) - normal tension glaucoma , ophthalmology , glaucoma , nerve fiber layer , medicine , visual field , retinal , nerve fibre layer , optic nerve , cluster (spacecraft) , open angle glaucoma , computer science , programming language
Purpose To investigate differences in progression patterns of normal‐tension glaucoma patients in three clusters classified by Hierarchical cluster analysis (HCA). Method 200 eyes of NTG patients classified by HCA in 2015 who were followed up until now were included. We evaluated the progression rate of NTG in SD‐OCT and visual field test and compared characteristics of the progression in each group. Result A total of 153 patients were followed up and the mean observation period was 5 years. In cluster 1, which showed early glaucomatous damage in the previous report, the mean retinal nerve fiber layer (RNFL) reduction rate was −0.83 μm/year. In cluster 2, which showed moderate glaucomatous damage, the reduction rate was −0.45 μm/year, and In cluster 3, which showed young and myopic glaucomatous damage, the rate was −0.36 μm/year. The progression pattern of cluster 3 showed a double‐peak distribution with the RNFL reduction rate being 0.11 μm/year in non‐progressive group and −1.07 μm/year in progressive group. Conclusion When the optic nerve head parameters were classified by HCA, the divided groups showed different patterns of NTG progression. In particular, the group of young myopia showed a mixture of two different patterns. /