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Subclinical choroidopathy in systemic lupus erythematosus
Author(s) -
DiasSantos Arnaldo,
Ferreira Joana,
Pinheiro Sofia,
Paulo Cunha João,
Alves Marta,
Luísa Papoila Ana,
Francisca MoraesFontes Maria,
Proença Rui
Publication year - 2019
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2019.5183
Subject(s) - medicine , subclinical infection , lupus nephritis , nephritis , cardiology , systemic disease , gastroenterology , disease
Purpose To compare choroidal thickness (CT) between patients with systemic lupus erythematosus (SLE) without ophthalmologic manifestations and a control group. To study the effects in CT of disease duration, disease activity index, medication and systemic comorbidities. Methods Cross‐sectional study where spectral‐domain optical coherence tomography with enhanced depth imaging was used to measure CT in 13 locations, subfoveally and at 500‐µm intervals along a horizontal and a vertical section from the fovea. Linear regression models were used. Results Sixty‐eight SLE patients and fifty healthy controls were enrolled. CT multivariable results showed a trend toward lower values in SLE patients (12.93–26.73 µm thinner) in all locations, except the inferior quadrants (6.48–10.44 µm thicker). Contrary to the control group, the normal topographic variation in CT between macular quadrants and form the center to the periphery was not observed in the SLE group. Multivariable analysis in SLE group alone revealed a significant negative association with anticoagulants (50.10–56.09 µm thinner) and lupus nephritis (40.79–58.63 µm thinner), and a positive association with secondary Sjogren’s syndrome (73.07 µm thicker). Contrary to controls, SLE patients’ CT did not respond to changes in mean arterial pressure. Conclusions CT in SLE appears to be thinner, particularly in the subset of patients with nephritis and taking anticoagulants, suggesting more advanced systemic vascular disease. Choroidal responses to hemodynamic changes may also be altered in SLE.