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Influence of coenzyme Q10 on ocular surface mıcrobıata
Author(s) -
Kocaturk Tolga,
Telli Murat,
Korkmazgil Berna,
Bilgen Mehmet
Publication year - 2019
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2019.5088
Subject(s) - microorganism , staphylococcus aureus , turbidity , microbiology and biotechnology , candida albicans , contact lens , bacterial growth , coenzyme q10 , bacteria , chemistry , eye care , q10 , in vitro , corpus albicans , biology , food science , biochemistry , botany , respiration , medicine , ophthalmology , ecology , genetics , optometry
Purpose To evaluate the effects of Coenzyme Q10 on the proliferation of the most common ocular surface bacteria; S. aureus , P. aeruginosa and fungus; C. albicans . Methods Experiments were performed in‐vitro with total 15 glass tubes of each filled with 1.5 mL. of fluid media were prepared. The tubes were then divided equally into three groups to culture the bacteria S. aureus , P. aeruginosa and fungus C. albicans . In a set of 5 tubes, colony of each microorganism was thus produced. In each group, Tube (numbered 0) was established as a control. The remaining Tubes 1–4 were respectively added with 1–4 drops of CoQ10 containing eye drops. The tubes were then evaluated at 0, 1, 2, 4, 5 and 24 hr. The proliferation of microorganism in a liquid medium resulted in turbidity from which microbial concentration was estimated using McFarland barium sulphate turbidity standard. Measurements were performed on the spectrophotometer as McFarland standard and interpreted through the changes in reproduction. For each group, the estimates of the average numbers of the corresponding microorganisms subjected to the four different strengths of CoQ10 were recorded and statistically compared to those in the control group. Results In all the groups, the concentrations of the microorganisms ( S. aureus , P. aeruginosa and C. albicans ) increased with time. However, exposure to CoQ10 containing eye drops did not significantly alter the microorganismal growth as the measurements from the CoQ10‐instilled tubes remained comparable to those of the controls. Conclusion CoQ10 under in‐vitro conditions did not induce proliferation of S. aureus , P. aeruginosa and C. albicans .