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The cis‐regulatory logic of photoreceptors and bipolar cells
Author(s) -
Corbo Joseph
Publication year - 2019
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2019.5024
Subject(s) - multicellular organism , transcription factor , chromatin , biology , transcriptome , genetics , functional divergence , computational biology , evolutionary biology , microbiology and biotechnology , cell , gene , gene expression , gene family
Abstract Multicellular organisms evolved via repeated functional divergence and subspecialization of transcriptionally related, but distinct sister cell types. In this talk, I describe the cis ‐regulatory logic of two canonical sister cell types in the retina: photoreceptors and bipolar cells. Although these cell types have highly divergent transcriptional profiles and open chromatin maps, they share remarkably similar cis ‐regulatory grammars. I present evidence that the presence/absence of a single key transcription factor binding site motif played a key role in the evolutionary divergence of the bipolar transcriptome from that of photoreceptors.

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