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Correlation between electrophysiological test and visual dysfunction in multiple sclerosis patients
Author(s) -
Vildades Palomar E.,
Orduna Hospital E.,
Ciprés M.,
Obis J.,
Rodrigo SanJuan M.J.,
Satué Palacian M.,
GarciaMartin E.
Publication year - 2017
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2017.0t035
Subject(s) - medicine , electrophysiology , ophthalmology , optic neuritis , multiple sclerosis , contrast (vision) , evoked potential , visual acuity , audiology , electroretinography , retinal , optics , psychiatry , physics
Purpose Evaluate best corrected visual acuity ( BCVA ), contrast sensitivity ( SC ), pattern electroretinogram ( pERG ), multifocal electroretinogram (mf ERG ), and multifocal visual evoked potentials (mf VEP ) in multiple sclerosis ( MS ) and compare with healthy controls. Methods Fifty‐eight eyes were included: 14 of healthy controls and 44 of subjects with MS (of whom 17 presented a previous episode of optic neuritis). The BCVA ETDRS was recorded at 100% contrast, 2.5% and 1.25%, CS with CSV 1000 test (at 3, 6, 9 and 12 cycles per degree) and Pelli Robson. The pERG , mf ERG and mf VEP electrophysiology tests were performed with the Roland Consult's Reti‐port / scan device. Results Patients with MS showed a significant reduction of VA at 100% contrast (p = 0.013), 2.5% (p <0.001) and 1.25% (p = 0.008), CSV ‐1000 was also affected at 3 (p = 0.017), 9 (p = 0.017), and 12 cycles per degree (p = 0.048), and also Pelli Robson (p <0.001). The mf ERG showed in MS patients a significant affectation for amplitude and latency at the inferonasal and superonasal quadrants (p = 0.045 and 0.042 respectively), and the overall values of the mf PEV sown abnormalities at N1 and P1 amplitudes (p = 0.019 and p = 0.039, respectively). Conclusions Patients with MS have a clear impairment of visual function in both psychophysical and electrophysiological tests.