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Molecular diagnostics of ocular allergy
Author(s) -
Vitte J.,
Baye A.,
Batellier L.,
Doan S.,
Bury T.
Publication year - 2017
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2017.03353
Subject(s) - culprit , medicine , allergy , immunoglobulin e , provocation test , allergen , immunology , allergic conjunctivitis , dermatology , antibody , pathology , alternative medicine , myocardial infarction
Summary Ocular allergies may severely impact on daily activities and overall quality of life. Conventional allergy testing with skin prick tests and circulating serum immunoglobulin E often falls short of identifying the culprit ocular allergens. On the other hand, targeting the ocular milieu may prove valuable for ocular allergy diagnostics. Conjunctival provocation testing and specific immunoglobulin E detection in tear fluid provide data on local ocular hypersensitivity. We focused on specific IgE testing by means of a commercial allergen microarray ( ISAC ® 112, Thermo Fisher Scientific). We report here the contribution of allergen microarray testing to identifying the culprit allergen in a 42‐year old woman presenting with perennial allergic conjunctivitis.