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Inflammatory biomarkers of the tear proteome in anterior segment disease
Author(s) -
Beuerman R.,
Zhou L.
Publication year - 2017
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2017.02762
Subject(s) - inflammation , proteome , proteomics , tears , medicine , rage (emotion) , disease , heat shock protein , bioinformatics , immunology , pathology , biology , neuroscience , biochemistry , gene
Summary Ocular surface inflammation is linked to a number of adverse outcomes which vary depending on adjunct factors such as recent surgery or presence of disease. Usually the level of inflammation is thought to be important in the evaluation. However, from a clinical point of view there are limited methods of evaluating inflammation. Proteomics allows the simultaneous accurate quantification of a large number of proteins associated with inflammation using just a few microliters of tears so that individual patients can be evaluated. For example, studies have shown several members of the S100 family of proteins which are contain 2 EF hand calcium binding motifs to be upregulated in dry eye and pterygium. The S100 proteins can bind to RAGE receptors on immune cells to stimulate further inflammation. Other proteins associated with inflammation include various heat shock proteins such as HSPA 8, 70 kDa protein. YWHAZ is found which is associated with cell injury and may be directly related to the type of pathology. Thus, using proteomics a more complete picture of the ocular surface inflammation can be developed and used to predict clinical outcomes.