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Pathophysiology of macular interface
Author(s) -
Kalemaki M.
Publication year - 2017
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2017.02715
Subject(s) - pathophysiology , macular hole , medicine , epiretinal membrane , ophthalmology , pathology , visual acuity , vitrectomy
Purpose To study the pathophysiology of the vitreomacular interface disorders (epiretinal membrane, macular hole, vitreomacular traction syndrome). Methods Retrospective review of published articles concerning the above entities. Results Posterior Vitrous Detachement ( PVD ) variations have been considered to be the initial event leading to vitreomacular interface abnormalities. Depending on the level of PVD (eg schisis, partial or complete), different pathophysiological cataracts may occur involving a number of cells and growth factors at the vitreomacular interface. Conclusions The pathophysiology of the vitreomacular interface includes a sequence of events such as cellular migration, proliferation and modulation of the extracellular matrix. The quality and quantity of the involved cells and growth factors vary between different vitromacular interface disorders.