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The potential impact of new OCT technology for the measurement of ocular inflammation
Author(s) -
Pichi F.
Publication year - 2017
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2017.02134
Subject(s) - medicine , context (archaeology) , iris (biosensor) , volume rendering , angiography , ophthalmology , uveitis , anterior uveitis , clinical practice , radiology , rendering (computer graphics) , computer science , artificial intelligence , paleontology , family medicine , biometrics , biology
Summary One of the greatest challenges when caring for patients with sight‐threatening uveitis is the lack of objective markers of disease activity, whether in the context of routine clinical practice (to direct treatment) or for use in clinical trials (to establish efficacy of new therapies and standardization of care). For example, the use of slit‐lamp microscopy to grade anterior chamber cells is quiet subjective, depending on the empirical ability of the grader, thus nowadays spectral domain‐ OCT can be used to highlight cells in the anterior chamber, and new automated algorithm are being developed to measure the number of cells in a 3D volume scan. In the anterior segment the iris tissue bed would also be a desirable site to monitor the progression of acute anterior uveitis, in which it is well known that the iris vessels dilate. OCT angiography is a novel technique that uses motion‐contrast imaging to non‐invasively create depth‐resolved angiographic maps of the vasculature. As such, OCT angiography can be used to analyze the iris vasculature in acute anterior uveitis, and new software are available to isolate the iris vessels, create a 3D rendering and measure the vasculature volume.