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Nanostructured hydroxyapatite used as an augmenting material to expand the orbit
Author(s) -
Popa Cherecheanu A.,
Istrate S.,
Iancu R.,
Popescu M.,
Bastian A.,
Ciuluvica R.
Publication year - 2017
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2017.01192
Subject(s) - implant , cd31 , orbit (dynamics) , biomedical engineering , materials science , neovascularization , medicine , surgery , angiogenesis , engineering , aerospace engineering
Purpose To test the nanostructured hydroxyapatite as an augmenting material to expand the orbit after initial placement of a porous implant. Methods Nanostructured hydroxyapatite powder mixed with blood was surgically introduced in the scleral sac of 6 eviscated rabbits (Oryctolagus cuniculus europaeus) after previous placing of a porous hydroxyapatite integrated implant (proved by CT scan). CT scans were done at 1, 2 and 3 months postsurgical to demonstrate the integration of the injected material in the porous implant. The scleral sac wes removed after 3 months and histopathologic examination plus CD 31 + (as a marker of neovascularization and osteosinthesis) were performed. Results CT scans performed at 1, 2 and 3 months postoperatively and the rapid development of CD 31 + osteoclasts and vascular tissue pleade for a good integration of the new material in the previous porous hydroxyapatite implant. Conclusions This method can be used for enhancing the volume of a small scleral sac with a previous hidroxyapatite implant. Further studies should be performed.