Premium
Differential diagnosis of cystoid macular edema by optic disc thickness in optical coherence tomography
Author(s) -
Cardigos J.,
Crisostomo S.,
Basilio A.,
Costa L.,
Carvalho B.,
Vieira L.,
Flores R.
Publication year - 2017
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2017.01186
Subject(s) - medicine , ophthalmology , macular edema , optical coherence tomography , optic disc , nerve fiber layer , visual acuity , fluorescein angiography , edema , diabetic retinopathy , diabetes mellitus , retinal , surgery , endocrinology
Purpose The differential diagnosis between Irvine‐Gass Syndrome ( IGS ) and Diabetic Macular Edema ( DME ) is currently established by angiography, which is an invasive and time‐consuming tool. The aim of this study is to evaluate differences in optic disc's nerve fiber layer thickness ( RNFL ) in patients with macular edema associated with IGS and Diabetes Mellitus ( DM ). Methods Retrospective case control study of 28 eyes of 28 patients with macular edema divided into 2 groups. Group 1 included 14 eyes with IGS diagnosed by clinical and angiographic criteria and group 2 included 14 eyes with cystoid diabetic macular edema ( DME ) without previous ocular surgery. A control group (group 3) of 14 eyes of 14 healthy patients paired by age and gender were also included. Ophthalmologic examinations included visual acuity ( VA ) measurements, slit‐lamp examination, Goldmann applanation tonometry, Spectral‐Domain Optic Coherence Tomography ( SD ‐ OCT ) and fluorescein angiography. Results Forty two patients (21 females and 21 males), with a mean age of 66.57 ± 10.80 years were included in this study. Optic disc nasal and temporal RNFL thicknesses as well as central macular thickness were significantly higher in group 1 and 2 compared with control group (p < 0.05). Nasal RNFL thickness was higher in IGS than in patients with DME (p < 0.001). To detect IGS (Group 1), comparative to DME (Group 2), using Nasal RNFL thickness, the area under the curve was 0.842 p < 0.002. A cut‐off criterion of 82.50 μ m resulted in 92.9% sensitivity and 71.4% specificity. Conclusions Optic disc SD ‐ OCT imaging might be a useful diagnostic tool to differentiate IGS from DME .