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Changes of anterior chamber morphometry with age in children using hand‐held spectral domain optical coherence tomography
Author(s) -
Edawaji B.,
Proudlock F.,
Gottlob I.
Publication year - 2017
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2017.01124
Subject(s) - optical coherence tomography , anterior chamber angle , ophthalmology , trabecular meshwork , glaucoma , medicine , nuclear medicine , anatomy
Purpose To identify the change of anterior chamber measurements with age in children using Hand‐Held Spectral Domain Optical Coherence Tomography ( HH ‐ SDOCT ). Methods A cross‐sectional study involved 93 normal children (mean age = 5.19 ± 4.1 years, range: 2 days to 15 years). HH ‐ SDOCT ( Leica Microsystems Ltd ) was used to image anterior chamber angle. B‐scan showing both clear nasal and temporal angles were analysed using ImageJ. The iridocorneal angle landmarks: scleral spur ( SS ), Schwalbe`s line ( SL ) and angle recess ( AR ) were identified and used to calculate trabecular meshwork length ( TML ), scleral spur angle opening distance ( SSAOD ), Schwalbe`s line angle opening distance ( SLAOD ), trabecular iris surface area ( TISA ), TISA 500, SS limbal distance ( SSLD ) and SL limbal distance ( SLLD ), nasal SS to temporal SS distance ( SS ‐ SSD ), nasal SL to temporal SL distance ( SL ‐ SLD ) and pupil diameter ( PD ). Linear mixed models were used to determine the correlation between ocular parameters and demographic data with log age. Results All measured parameters were significantly influenced by age (all P values <0.05). The changes of parameters per age were measured in 591 angle images. In the first year, TML increased by 159.6 μ m (30.5%), SSAOD 120.4 μ m (112.4%), SLAOD 347.4 μ m (95.7%), TISA 0.19 mm² (133.4%), TISA 500 0.13 mm² (96.4%), SSLD 33.7 μ m (4.2%), SLLD ‐ 30.3 μ m (3.9%), SS ‐ SSD 2.4 mm (23.3%), SL ‐ SLD 2.0 mm (21.4%) and PD 2.4 mm (114.3%). No significant changes were detected with gender or between both eyes ( P values > 0.05). Conclusions HH ‐ SDOCT can be an effective technique in understanding the morphometric changes of anterior chamber in children from birth. Our findings highlight the need for normative age adjusted data to detect abnormalities in angle measures clinically.