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SD‐OCT for study of retinal layers segmentation in patients under Hydroxychloroquine treatment
Author(s) -
Costa L.,
Basílio A.L.,
Proença R.,
Cunha J.P.,
Vieira L.,
Flores R.,
Santos A.
Publication year - 2016
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2016.0676
Subject(s) - hydroxychloroquine , outer nuclear layer , retinal , medicine , ophthalmology , optical coherence tomography , inner nuclear layer , retina , optics , covid-19 , disease , physics , infectious disease (medical specialty)
Purpose Hydroxychloroquine has been used for decades in treatment of rheumatic disorders. Macular toxicity is an adverse effect dependent to duration of treatment and daily dosage. Although, the exactly retinal structure under this toxic effect is not yet totally understandable. To study the sectorial effect of Hydroxychloroquine in all retinal layers in 1st, 2nd, 3th and 6th mm centered on fovea by automatic segmentation using Spectral‐Domain Optical Coherence Tomography. Methods Retrospective, non‐randomized study involving 44 eyes of 44 patients under treatment with Hydroxychloroquine. The authors have created two age‐matched groups. A group 1 of patients in treatment duration under 10 years ( n = 30) and a group 2 above 10 years of treatment ( n = 14). Results The inner retinal layers thickness of 1st and 2nd mm is impaired in group 2 but the results did not showed significant difference between groups. The automatically segmentation of layer by layer did not prove a sectorial defect in inner retina. The thickness of Outer Nuclear Layer (ONL) was impaired in group 2, in opposition to Outer Plexiform Layer (OPL). This analysis has demonstrated a tendency for inversion of ONL and OPL thickness values in both groups. Conclusions The toxicity of Hydroxychloroquine apparently was not responsible for significant alterations in inner retinal thickness. That is a tendency for reduction in ONL thickness. The higher thickness of OPL in group 2 is a surprising aspect that needs additional analysis. The outcomes were very dependent to the limited number of patients in our sample. Further longitudinal studies about this topic will be necessary.