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Late intraocular relapses in retinoblastoma
Author(s) -
Hadjistilianou D.,
Borri M.,
Defrancesco S.,
Munier F.,
Galluzzi P.,
Bracco S.,
Galimberti D.,
Menicacci F.,
Coriolani G.
Publication year - 2016
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2016.0652
Subject(s) - retinoblastoma , medicine , complete remission , radiation therapy , surgery , chemotherapy , spontaneous remission , pathology , biochemistry , chemistry , alternative medicine , gene
Purpose To report very late intraocular relapses in 6 patients treated for bilateral retinoblastoma. Methods we rewied the charts of 6 children who presented late intraocular recurrences of retinoblastoma. Three were familial and three sporadic cases. The patients achieved first remission after treatment with neoadjuvant chemotherapy, external radiotherapy and focal therapy. Relapses ocurred after 6–17 years after first remission . Results Three out of six patients are currently in second complete remission after receiving futher treatments. Two cases were enucleated and one is still under treatment. Therapeutic approach is reported and discussed for each case. Conclusions Retinoblastoma usually recurs within the first few years after treatment completion. Late and very late intraocular relapses are very rare but do ocur. A long‐term and close follow‐up is needed for early detection of late recurrences.