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Correlation between retinal and mixed venous oxygen saturation
Author(s) -
Van Keer K.,
Abegão Pinto L.,
Stalmans I.,
Vandewalle E.
Publication year - 2016
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2016.0650
Subject(s) - retinal , medicine , cardiology , oxygen saturation , transplantation , correlation , ophthalmology , oxygen , chemistry , mathematics , organic chemistry , geometry
Purpose To investigate the correlation between mixed venous (SvO 2 ) and retinal vessel (SrO 2 ) oxygen saturation, using non‐invasive spectroscopy in pre‐ and post‐ heart transplant patients. Methods Retinal oxygen saturation and vessel caliber were measured in dark‐adapted patients, breathing ambient air in a seated position, using dual wavelength retinal oximetry, within 24 h of a SvO 2 sampling during right heart catheterization. Correlations were analyzed using Pearson correlation coefficients and linear regression models. Results Twelve patients aged 57.4 ± 18.2 years were analyzed. A strong negative correlation was found between retinal arteriovenous oxygen difference and SvO 2 ( r = −0.64, p = 0.024), as well as between retinal arterial diameter and time since heart transplantation ( r = −0.77, p = 0.009), independent of demographic and systemic parameters. Conclusions Retinal oximetry provides a non‐invasive method to visualize and quantify the oxygen saturation of arteries and veins of the central circulatory system. This pilot study provides proof of concept for the use of retinal oximetry in the follow‐up of patients after heart transplantation, to assess cardiac function as well as cardiovascular health.