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The oxygen saturation in retinal arterioles is predictive for the effect of intravitreal anti‐VEGF treatment on diabetic macular edema
Author(s) -
Bek T.
Publication year - 2016
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2016.0648
Subject(s) - retinal , medicine , diabetic retinopathy , ophthalmology , oxygen saturation , maculopathy , retinopathy , diabetes mellitus , saturation (graph theory) , oxygen , endocrinology , chemistry , organic chemistry , mathematics , combinatorics
Summary It has been shown that the oxygen saturation in retinal vessels is increased in patients with diabetic maculopathy, but the role of this parameter for the effect of anti‐VEGF treatment of the disease is unknown. Therefore, the predictive value of oxygen saturation in larger retinal vessels for the effect of anti‐VEGF treatment of diabetic maculopathy was studied. In 73 eyes from 53 patients with center involving diabetic macular edema the predictive value of oxygen saturation in larger retinal vessels and other risk factors for retinopathy progression as explanatory variables was studied for visual acuity (VA) and central retinal thickness (CRT) after anti‐VEGF treatment as effect variables. Anti‐VEGF treatment induced a significant increase in VA and a signficant decrease in CRT, but no significant changes in the overall oxygen saturation of larger retinal vessels. In a multiple regression model VA and CRT obtained before treatment contributed significantly to predicting the effect of treatment on the same variable. Mean arterial blood pressure and the oxygen saturation in retinal arterioles before treatment contributed signficantly to predicting both VA and CRT after treatment. The oxygen saturation in retinal arterioles is a new parameter that might potentially be included in risk models predicting the effect of anti‐VEGF treatment on diabetic maculopathy.