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A vascular comparison between primary open‐angle glaucoma and normal‐tension glaucoma
Author(s) -
Van Keer K.,
Abegão Pinto L.,
Barbosa Breda J.,
Willekens K.,
Vandewalle E.,
Stalmans I.
Publication year - 2016
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2016.0646
Subject(s) - medicine , normal tension glaucoma , glaucoma , ophthalmology , ophthalmic artery , intraocular pressure , retinal , retinal artery occlusion , central retinal artery , open angle glaucoma , blood pressure , odds ratio , cardiology , blood flow
Purpose To contrast systemic and ocular vascular parameters in patients with normal‐tension glaucoma (NTG) versus primary open‐angle glaucoma (POAG). Methods Sub‐analysis of a prospective, cross‐sectional, case–control hospital‐based study investigating ocular blood flow in glaucoma patients (Leuven Eye Study). Systemic and ocular vascular parameters, including a questionnaire, blood pressure, dynamic contour tonometry, colour Doppler imaging, retinal oximetry and optical coherent tomography enhanced‐depth imaging, were compared between an age‐matched group of POAG and NTG patients. Results We included 192 NTG and 214 POAG patients. Patients with NTG presented with significantly lower diastolic blood pressure (p = 0.01), decreased acceleration in the central retinal artery (p = 0.02), increased resistive index in the ophthalmic artery and central retinal vein (both p = 0.04), thinner peripapillary choroidal thickness (p < 0.001) and higher retinal venous oxygen saturation (p < 0.001). The odds of suffering from hypotension, migraine and Raynaud were significantly higher for NTG patients [95% confidence interval (CI) 1.30–8.73, 1.13–4.42 and 1.36–3.95 respectively], as were the odds of taking systemic bèta‐blockers, calcium antagonists and angiotensin II receptors blockers (95% CI 1.04–2.67, 1.21–6.62 and 1.18–5.97 respectively). Conclusions Patients with NTG differ significantly on several ocular and systemic vascular parameters from POAG patients. These findings add further support to a higher weight for vascular‐driven neuropathy in NTG vascular etiology in NTG.