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Analysis of the peripapillary retinal nerve fiber layer and choroidal thickness in patients with Parkinson's disease using swept‐source optical coherence tomography
Author(s) -
Obis J.,
Cipres Alastuey M.,
Villades E.,
GarciaMartin E.,
Satue M.,
Rodrigo M.J.
Publication year - 2016
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2016.0574
Subject(s) - nerve fiber layer , retinal , ophthalmology , medicine , choroid , inner nuclear layer , optical coherence tomography , inner limiting membrane , nerve fibre layer , retina , optics , physics
Purpose To analyze the thickness of several retinal layers and the thickness of the choroid in the peripapillary area in patients with Parkinson's disease (PD) using swept‐source optical coherence tomography (SS‐OCT) as a marker for neurodegenerative injury. Methods 108 eyes of patients with PD and 90 eyes of healthy controls were included. All subjects underwent ophthalmologic evaluation, including retinal and choroidal assessment using SS‐OCT Triton (Topcon), 3DH Wide protocol. RNFL‐TSNIT data were analyzed in the peripapillary area, including retinal nerve fiber layer (RNFL), GCL+ layer (from RNFL to inner nuclear layer), GCL++ layer (from inner limiting membrane to inner nuclear layer) and choroidal thickness. Results Patients with PD revealed significant thinning in every retinal layer compared to healthy controls: average retinal thickness (280.25 ± 20.18 μ m in patients vs. 288.18 ± 13.09 μ m in controls; p = 0.013); inferotemporal sector of the RNFL thickness (135.08 ± 25.28 μ m vs. 144.23 ± 17.19 μ m; p = 0.024); superotemporal sector of the GCL+ layer thickness (38.52 ± 7.02 μ m vs. 41.78 ± 9.24 μ m; p = 0.047); inferotemporal sector of the GCL++ layer thickness (176.00 ± 28.07 μ m vs. 187.07 ± 16.93 μ m; p = 0.010). Contrary, patients with PD revealed significant thickening in total choroidal thickness compared to healthy controls (153.56 ± 62.48 μ m in patients vs. 125.64 ± 52.53 μ m in controls; p = 0.012), choroidal nasal (152.73 ± 50.54 μ m vs. 129.32 ± 54.86 μ m; p = 0.024), choroidal temporal (165.82 ± 80.16 μ m vs. 128.40 ± 50.81 μ m; p = 0.003) and choroidal inferior thickness (129.90 ± 64.70 μ m vs. 98.83 ± 51.67 μ m; p = 0.006). Conclusions Patients with PD present significant reduction of peripapillary retinal, RNFL and ganglion cell layer thickness and significant thickening of the choroid in the peripapillary area detectable with new SS‐OCT technology.