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Combination of global electroretinogram and sd‐oct in the etiology of infantile nystagmus
Author(s) -
Bouladi M.,
Bouraoui R.,
Limaiem R.,
Chaker N.,
Mghaieth F.,
El Matri L.
Publication year - 2016
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2016.0506
Subject(s) - etiology , medicine , nystagmus , erg , ophthalmology , achromatopsia , electroretinography , pediatrics , audiology , retinal
Purpose To study the combination of global electroretinogram (ERG) and SD‐OCT in the etiology of infantile nystagmus. Methods Sixteen children with infantile nystagmus, and no evident etiology in the normal ophthalmic examination underwent ERG with ISCEV guidelines and SD‐OCT. Results Median age was 8.7 ± 2.9 years (3.4–14.6 years). ERG and SD‐OCT were both normal in 6 children. In 9 children, ERG showed cone dysfunction and OCT allowed differentiation between achromatopsia in 4 children and cone dystrophy in 5 children. Two children had rod and cone dysfunction in ERG and OCT was normal. Dysfunction in inner‐layer retina was found in one child who had X‐linked juvenile retinoschisis diagnosed with OCT. Conclusions ERG is useful in the etiologic diagnosis and prognosis of infantile nystagmus. Its combination with SD‐OCT allows better characterization of the etiology of nystagmus especially in diseases involving the macula which may guide molecular study, help performing genetic counseling, and facilitate future gene therapy.