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Macular thickness in diabetic eyes without clinical macular edema
Author(s) -
García Zamora M.,
Montero Moreno J.A.,
Gonzalez Uruena C.,
Frances Caballero E.,
FernandezMunoz M.
Publication year - 2016
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2016.0497
Subject(s) - ophthalmology , medicine , retinal , diabetic retinopathy , nerve fiber layer , optical coherence tomography , macular edema , diabetes mellitus , diabetic macular edema , fovea centralis , population , foveal , environmental health , endocrinology
Purpose To evaluate macular thickness of individuals with moderate diabetic retinopathy (DR) without macular edema (DME). Methods Retinal thickness was calculated by automated segmentation of spectral domain‐optical coherence tomography scans of patients with moderate DR without DME and compared with an age‐matched population of non‐diabetic individuals. Mean values and multiple linear regression analysis were used to determine the relationship between retinal layers thickness and age, sex, diabetes type and concentration of glycosylated hemoglobin (HbA1c). Results A total of 66 eyes were studied, 34 eyes with moderate DR without DME or previous treatment and 32 eyes from non‐diabetic individuals. The mean retinal nerve fiber layer (RNFL) thickness in the superior parafoveal area of patients with DR was 29.88 μ m vs. 23.18 μ m in the non‐diabetic group (p = 0.01). The mean inner nuclear layer thickness in the central fovea area in the DR group was 28.26 μ m vs. 22.87 μ m in the non‐diabetic control group (p = 0.01). There was a significant linear correlation ( R = 0.353, p = 0.04) between HbA1c and the inner nuclear layer thickness in the superior parafoveal area. Conclusions According to our findings, DR patients showed an increase of macular thickness compared with the non‐diabetic control group in the superior parafoveal and central foveal area. Increased HbA1c levels may play a role in the increased macular thickness.