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MiRNA‐126 regulation in corneal neovascularization
Author(s) -
Zhang H.
Publication year - 2016
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2016.0489
Subject(s) - microrna , gene silencing , biology , trans acting sirna , rna interference , rna , rna silencing , rna induced silencing complex , genetics , small interfering rna , messenger rna , non coding rna , argonaute , gene , gene expression , computational biology , post transcriptional regulation , untranslated region , microbiology and biotechnology
Summary A microRNA (abbreviated miRNA) is a small non‐coding RNA molecule (containing about 22 nucleotides) that functions in RNA silencing and post‐transcriptional regulation of gene expression. miRNAs derive from regions of RNA transcripts that fold back on themselves to form short hairpins and resemble the small interfering RNAs (siRNAs) of the RNA interference (RNAi) pathway. The human genome may encode over 1,000 miRNAs, which appear to target about 60% of the genes of humans and other mammals. A miRNA is complementary to the 3′ UTR of one or more messenger RNAs (mRNAs) and has post translational regulation of the mRNAs. MiRNAs are known to be involved in the normal functioning of eukaryotic cells as well as many diseases. However, little is known about the role of microRNA in ocular diseases. We tested the microRNA expression in both corneal neovacualrization patients and animal models.