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Factors determining the prelaminar tissue thickness in glaucoma
Author(s) -
Rebolleda G.,
Diez Alvarez L.,
Casas LLera P.,
Cabarga C.,
De Juan V.,
MuñozNegrete F.J.
Publication year - 2016
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2016.0462
Subject(s) - ophthalmology , glaucoma , nerve fiber layer , intraocular pressure , bruch's membrane , retinal , medicine , optic nerve , anterior chamber angle , optical coherence tomography , optic disk , visual field , optic disc , cirrus , anatomy , retinal pigment epithelium , physics , meteorology
Purpose To identify demographic, anatomic and functional factors associated withthe prelaminar tissue thickness (PTT) and LC (thickness and depth) in primaryopen angle glaucoma (POAG). Methods Cross‐sectional study including 60 patients with POAG.The optic nerve head was imaged usingthe enhanced depth imaging (EDI) technology of Spectralis optical coherencetomography (OCT). The vertical distances from three equidistant points on thereference line (Bruch's membrane opening) to the anterior prelaminar tissuesurface and the anterior and posterior surfaces of the LC were manually measured.Analyzed factors associated with the PTT and LC thickness and depth includedage, central corneal thickness, axial length (AL), intraocular pressure (IOP),rim and disc areas (OCT‐Cirrus), retinal nerve fiber layer (RNFL) averagethickness (OCT‐Spectralis), ganglion cell layer and inner plexiform layer (GCIPL) average thickness (OCT‐Cirrus) and meandeviation (MD) in visual field. Results Significantassociations were found between the PTT and age (−0.317; p = 0.014), disc and rim areas (−0.544; p = 0.005 and 0.772; p < 0.001respectively), BMO diameter (−0.332; p = 0.01), RNFL and GCIPL average thickness (0.642; p < 0.001 and 0.663; p < 0.001, respectively) and MD (0.584; p < 0.001). LC depth correlated with age (−0.267; p = 0.041), rim area (−0.466; p = 0.019) and cup depth (0.849; p < 0.001). A negative association wasalso demonstrated between AL and LC thickness (−0.53; p = 0.01). As expected, MDwas significantly correlated with cup depth. Conclusions Theprelaminar tissue thickness was inversely correlated with age, anatomic (RNFL, CGIPL, disc and rim areas, BMO) and functional parameters (MD) in patients withPOAG, so that it can be considered together the LC a relevant structure in thepathophysiology of glaucoma.