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Effectiveness of platelet‐rich plasma treatment in patients with chronic corneal erosions, associated with Herpetic keratitis
Author(s) -
Loshkareva A.,
Maychuk D.
Publication year - 2016
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2016.0430
Subject(s) - medicine , cornea , keratitis , herpes simplex virus , ophthalmology , surgery , lesion , virus , immunology
Purpose 3 courses of platelet‐rich plasma (PRP) instillations were investigated for their effect on corneal epithelialization, in cases, associated with Herpetic keratitis Methods The study involved 21 patients with chronical corneal erosions of Herpetic keratitis origin. Etiology was confirmed by immunosorbent immunoglobulins M, G assay for Herpes Simplex Virus 1,2, Cytomegalovirus and Virus Epstein ‐ Barrie. All patients had previous unsuccessful courses of reparative therapy. First step of treatment consist of local and systemic antiviral therapy (Gancyclovir eye gel 0.15% and Valcyclovir). After the antiviral therapy, common volume 15 ml. of blood, taken from patients cubital vein, was mixed with anticoagulant (Sodium citrate with Dextrosa), and undergone a double centrifugation for 4 min. at 3,500 rpm. Patients were receiving: PRP instillations 6 times a day in combination with subconjunctival injection ones a week, Sulfated glicosaminoglicans 0.01% 4 times a day, Dexpanthenol 5% 4 times a day. Course of treatment was 3 weeks, procedure of obtaining PRP was performed 1 time per week. Dynamic of the treatment was assessed by Efron scale (cornea fluorescein coloring at 5 sectors in points). The patient's condition before therapy was used as a control. Results The average index of the corneal lesion before treatment was 9.7 points. After the 1st and 2nd procedure average lesion index was 8.2 and 5.9 points respectively. After 3 weeks, complete epithelization was observed in 12 patients. In 6 patients a gradual disappearance of the epithelial defects was shown after 5–6 courses. 3 patients did not respond to the treatment. Conclusions PRP treatment showed positive dynamic in cases of previously unsuccessfully treated chronical corneal erosion.