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Vessel diameter study: intravitreal versus posterior subtenon triamcinolone acetonide injection for diabetic macular edema
Author(s) -
Akpolat C.,
Kurt M.,
Cekic O.
Publication year - 2016
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2016.0403
Subject(s) - medicine , triamcinolone acetonide , ophthalmology , retinal , diabetic macular edema , edema , diabetic retinopathy , diabetes mellitus , surgery , endocrinology
Purpose To detect and compare the vessel diameter effect of intravitreal versus subtenon injection of triamcinolone for diabetic macular edema (DME). Methods Sixty patients with DME who underwent triamcinolone injection either intravitreally ( N = 30) or under the tenon capsule ( N = 30) were included. Non‐injected fellow eyes served as control. The main outcome measures were central retinal artery equivalent (CRAE), central retinal vein equivalent (CRVE), and artery‐vein ratio (AVR). Results In the intravitreal group, pre‐injection mean CRAE (147.07 μ ) decreased to 141.03 μ at 1 week and to 139.43 μ at 1 month (p < 0.001) while baseline CRVE (209.61 μ ) decreased initially to 198.85 μ at 1 week then to 198.49 μ at 1 month (p < 0.001). In the subtenon group, pre‐injection CRAE (152.18 μ ) decreased to 149.49 μ at 1 week and to 147.47 μ at 1 month (p = 0.017) while baseline CRVE (215.60 μ ) decreased initially to 208.69 μ at 1 week then to 207.25 μ at 1 month (p = 0.003). Pre‐injection AVR values did not change at 1 week and at 1 month in both injection groups (p = 0.66 and p = 0.196, respectively). In the control group, none of the 3 parameters changed throughout the study period compared to the baseline (p > 0.28). Conclusions In eyes with DME, both intravitreal and subtenon triamcinolone injection led to a significant constriction of retinal arteries and veins