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Wave‐amplitude differences between corneal and conjunctival electrodes for multifocal electroretinogram
Author(s) -
MunozNegrete F.J.,
Rebolleda G.,
Garcia Garcia A.
Publication year - 2016
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2016.0381
Subject(s) - medicine , ophthalmology , amplitude , electroretinography , electrode , intraclass correlation , erg , audiology , optics , retinal , physics , clinical psychology , quantum mechanics , psychometrics
Purpose To compare the wave amplitude of multifocal electroretinogram (mfERG) responses from DTL electrode located on the conjunctival fornix (fDTL) and ERG‐jet contact lens electrode (CL). Methods Thirty patients and 18 matched healthy volunteers were evaluated. Wave amplitude and level of discomfort with each electrode were compared in both patients and healthy volunteers. Comparisons among wave amplitudes were performed using Intraclass Correlation Coefficient Results mfERG by corneal electrode provided the highest wave amplitude in both healthy subjects and patients (p < 0.005), but it associated the highest discomfort (p < 0.001) and the highest rate of dislocations. CL was able to differentiate patients from controls just in the ring 1 (central 2°) of the mfERG. By contrast, fDTL provided the lowest wave amplitude but better discriminated between patients and control group in ring 1 (central 2°) and 2 (2–5°) of the multifocal ERG. cDTL produced significant more artifacts in both groups (p < 0.001). Conclusions Although mfERG wave amplitude measurements were correlated, they cannot be directly compared, so it is mandatory to create an appropriate normative database with each electrode. Despite providing the lowest amplitudes, fDTL seems to offer the best features to perform mfERG regarding discomfort, number of artifacts and diagnostic capability.