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Application of laser radiation exposed Chlorpromazine for the treatment of pseudotumours induced in rabbit eyes
Author(s) -
Popa Cherecheanu A.,
Tozar T.,
Geamanu A.,
Iancu R.,
Duta S.,
Pirvulescu R.
Publication year - 2016
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2016.0363
Subject(s) - chlorpromazine , irradiation , rabbit (cipher) , laser , antibiotics , medicine , stage (stratigraphy) , pharmacology , chemistry , biology , optics , computer science , biochemistry , physics , computer security , nuclear physics , paleontology
Purpose Multiple drug resistance (MDR) is a challenge that requires a flexible approach to find medicines able to overcome it. Among the methods used to overcome it, there is the exposure of existing medicines to UV laser beams to generate active photoproducts against bacteria and/or malignant tumors. Methods We studied the interaction of UV activate Chlorpromazine (CPZ) (irradiated with 266 nm pulsed laser beams), at concentrations of 10 and 20 mg/ml in ultrapure water, with rabbit eyes pseudotumors. Results The use of CPZ water solution exposed to 266 nm in the treatment of pseudotumor tissues produced on rabbit eyes shows that treatment results depend on initial (before irradiation) CPZ concentration and exposure time. At this stage, one may not specify which out of the generated photoproducts, individual or as a group, is/are efficient in pseudotumor cure but overall effects are observable. Application of CPZ irradiated solutions on rabbit eyes pseudotumors seems to produce a faster recovery of tissues with respect to control, untreated eyes. Conclusions Histologic findings in the treated tissues show a good antiinflamatory response. The results obtained open perspectives to fight MDR and/or development of pseudotumoral processes with substances that were not initially made for this purpose (non‐antibiotics, for instance).