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The immunohistochemical identification and localization of homocysteine in the human retina with the features of age related macular degeneration
Author(s) -
Ozimek M.,
Chorągiewicz T.,
Junemann A.,
Rejdak R.
Publication year - 2016
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2016.0251
Subject(s) - drusen , macular degeneration , retina , immunohistochemistry , pathology , medicine , homocysteine , pathogenesis , degeneration (medical) , ophthalmology , basal (medicine) , biology , neuroscience , endocrinology , diabetes mellitus
Purpose The purpose of this study was to determine the presence of homocysteine within the human retina with the features of age related macular degeneration. Methods Immunohistochemistry was performed using anti‐homocysteine rabbit polyclonal antibodies on sections of 7 human eyes enucleated because of the choroidal malignant melanoma. Results Homocysteine immunoreactivity was found in humane retina. It was present in soft drusen, basal deposits and RPE presenting abnormal morphology. Hard drusen presented no staining. Conclusions The presence of homocysteine in the human retina with the features of age related macular degeneration suggest that it may be involved in the pathogenesis of this eye disease.