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Retinal toxicity following intra‐vitreal injections of melphalan
Author(s) -
Munier F.,
Gaillard M.C.,
Stathopoulos C.,
BeckPopovic M.
Publication year - 2016
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2016.0218
Subject(s) - medicine , toxicity , melphalan , ophthalmology , retinoblastoma , retinal , retinopathy , surgery , chemotherapy , biochemistry , chemistry , gene , diabetes mellitus , endocrinology
Summary We report a retinal toxicity grading system as observed in a cohort of 110 retinoblastoma eyes treated by intra‐vitreal injections of melphalan to control vitreous seeding. By definition grade 1 and 2 correspond to a salt and pepper retinopathy anterior to the equator of 2 quadrants and 2 quadrants respectively; grade 3 any extension behind the equator, grade 4 extension involving the macula and grade 5 diffuse retinopathy with optic nerve atrophy. In our series grade 4 and 5 toxicity could be avoided in 100% of the cases. We conclude that our injection technique is safe enough to prevent severe sight‐threatening toxicity.