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Problems in the diagnosis of intraocular lymphoma
Author(s) -
Cassoux N.
Publication year - 2016
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2016.0180
Subject(s) - medicine , lymphoma , intraocular lymphoma , uveitis , pathology , biopsy , vitrectomy , ophthalmology , radiology , visual acuity
Summary Intraocular lymphoma means different entities. Primary vitreoretinal lymphoma can mascarade a chronic uveitis. This lymphoma is a subset of primary cerebral lymphoma. The disease is a B cell non hodgking lymphoma, aggressive, with a survival rate of less than 2 years after the occurrence of cerebral localization. Clinical examination, fluorescein angiography, OCT can be highly suggestive combined with resistance to corticosteroids. Diagnosis is based on cytokines levels (IL10/IL6) in aqueous humor or vitreous and diagnostic vitrectomy. Uveal localization of MALT lymphoma is rare and much more difficult to diagnose. This affection can mimic choroidal metastasis or a posterior scleritis or achromic uveal melanoma. The diagnosis can be suspected clinically (unpainfull choroidal thickening), hypoechogenic choroidal infiltration, typical aspect on ocular MRI. The diagnosis is based on episcleral, or choroidal biopsy.