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Retinal Oximetry and blood flow
Author(s) -
Hudson C.,
Rose K.,
Kulasekara S.,
Cheng R.,
Wong B.
Publication year - 2016
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2016.0149
Subject(s) - retinal , hyperoxia , retina , blood flow , hypoxia (environmental) , oxygen saturation , oxygen , ophthalmology , medicine , biology , chemistry , neuroscience , organic chemistry
Summary The retina has highest metabolic demand compared to any other tissue in the human body and regulation of the retinal blood flow, blood oxygen saturation (SO 2 ) and thereby oxygen delivery (DO 2 ) are crucial to preserve vision and function. The study reports inner retinal DO 2 and consumption (VO 2 ) during controlled and stable normoxia, hyperoxia and hypoxia in humans. Eleven subjects underwent measurement of total retinal blood flow (TRBF) and retinal blood oxygen saturation (SO 2 ) using prototype methodologies of Doppler Spectral Domain Optical Coherence Tomography and Metabolic Hyperspectral Camera, respectively. TRBF decreased significantly (p = 0.010) from 43.17 μ l/min (+12.7) to 36.23 μ l/min (+4.6) during hyperoxia, conversely, TRBF increased significantly (p < 0.008) to 52.89 μ l/min (+10.9) from baseline during hypoxia. The average inner retinal O 2 delivery during normoxia was 8.48 mlO 2 /100 g/min and inner retinal consumption was 3.64 mlO 2 /100 g/min and these values changed during provocation to maintain a stable DO 2 and VO 2 . Change in TRBF and SO 2 reflect metabolic autoregulatory function of the retinal tissue indicating that retinal blood flow and SO 2 are able to precisely compensate for changes in inspired oxygen.