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Developing new treatments for inherited retinal degenerations
Author(s) -
Maclaren R.
Publication year - 2016
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2016.0046
Subject(s) - blindness , retina , retinal , retinal degeneration , macular degeneration , retinitis pigmentosa , neuroscience , medicine , clinical trial , optometry , biology , ophthalmology , bioinformatics
Summary Retinal diseases are currently the leading causes of untreatable blindness in Europe. Most commonly, incurable blindness occurs when photoreceptors are lost and therapeutic strategies therefore aim to prevent photoreceptor cell death by genetic correction of single gene disorders. Once photoreceptors have degenerated, alternative strategies are required to regenerate the retina using biological approaches and subretinal electronic devices have also shown great promise in demonstrating that blindness may be potentially reversible. This lecture will provide an update on the application of scientific discovery in clinical trials for retinal degeneration and provide insight into the fascinating age of discovery that lies ahead.