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Multiloaded microparticulate drug delivery systems for the treatment of retinal diseases
Author(s) -
HerreroVanrell R.,
Arranz A.,
GarcíaCaballero C.,
Guzmán M.,
AndresGuerrero V.,
GarcíaFeijoo J.,
MolinaMartínez I.T.,
BravoOsuna I.
Publication year - 2016
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2016.0024
Subject(s) - retinal , medicine , drug , drug delivery , adverse effect , microsphere , drug administration , food and drug administration , pharmacology , intensive care medicine , ophthalmology , nanotechnology , materials science , chemical engineering , engineering
Summary Retinal degenerative pathologies are becoming more prevalent due to the increase in society longevity. As most of retinal diseases are multifactorial, successful therapy requires a combination of drugs. Furthermore, effective concentrations of active substances must be maintained in the retinal target site for long periods of time. Due to the poor accessibility of retinal tissues, intraocular injections of therapeutic molecules are needed with the risk of adverse events. Biodegradable multi‐loaded microspheres (MSs) offer an excellent alternative to multiple administrations as they are able to incorporate and deliver several therapeutic molecules in a controlled fashion for extended periods of time. Contrary to larger devices, administration of MSs is performed without the need of surgical procedures. Moreover, they disappear from the site of administration after delivering the drug. Personalized therapy can be easily achieved by selecting the amount of microspheres depending on patient's needs. Support: MICINN MAT 2013–43127R; UCM‐Research‐Group 920415, Oftared RD12/0034/0003.