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Effect of Preconditioning Intraocular Lenses in Moxifloxacin Solution
Author(s) -
Filipe H.P.,
Bozukova D.,
Pimenta A.,
Mata J.L.G.,
Colaço R.,
Saramago B.,
Serro A.P.
Publication year - 2015
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2015.0572
Subject(s) - moxifloxacin , endophthalmitis , staphylococcus epidermidis , cataract surgery , intraocular lenses , streptococcus pneumoniae , aqueous humor , medicine , ophthalmology , saline , antibiotics , staphylococcus aureus , anesthesia , intraocular lens , microbiology and biotechnology , biology , genetics , bacteria
Purpose The goal of our research was to investigate the possibility of using drug loaded intra‐ocular lenses (IOLs) as an alternative to topical antibiotic usually prescribed after cataract surgery. Methods Although widely used in drug release studies due to its simplicity in comparing systems, static conditions are far from reproducing biological conditions. A microfluidic cell mimetizing chamber's aqueous humor hydrodynamic is a much closer approach. With a volume of 250 µL, the cell is fed with a continuous flow of saline solution at a physiological similar rate. Results Results showed that 30 days preconditioned IOLs were able to maintain a MXF concentration above the minimum inhibitory concentrations for Staphylococcus aureus, Staphylococcus epidermidis and Streptococcus pneumoniae for 20 days. Conclusions Further investigation in using moxifloxacin loaded IOls as effective to prevent post cataract surgery endophthalmitis is encouraged.