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Use of retinal oximetry in estimating cerebral tissue oxygenation
Author(s) -
Van Keer K.,
Abegão Pinto L.,
Stalmans I.,
Vandewalle E.
Publication year - 2015
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2015.0548
Subject(s) - retinal , medicine , oxygenation , oxygen saturation , venous blood , ophthalmology , pulse oximetry , cardiology , oxygen , anesthesia , chemistry , organic chemistry
Purpose To investigate the correlation between cerebral tissue oxygenation (SctO 2 ) and retinal vessel oxygen saturation ( SO 2 ) using non‐invasive spectroscopy in healthy individuals. Methods Retinal and cerebral oxygen saturations were measured in dark‐adapted, healthy volunteers breathing ambient air in a seated position using dual wavelength retinal oximetry and transcranial near‐infrared spectroscopy ( NIRS ) respectively. Correlations between SO 2 and SctO2 were analyzed using Pearson correlation coefficients. Multivariate analysis was performed to determine the relative contribution of the arterial and venous vessels to SctO2. Using this model, SctO2 was estimated based on retinal arterial and venous oxygen saturation. Pearson correlation coefficients, paired sample t‐test and Bland‐Altman analysis were used to assess the agreement between the measured and the predicted SctO2. Results Twenty‐one young healthy individuals aged 26.4 ± 2.2 years were analyzed. SctO2 showed a significant positive correlation with both arterial and venous SO 2 (r = 0.442, P = 0.045 and r = 0.434 P = 0.049 respectively). In multivariate analysis, the relative contribution of arterial and venous SO 2 to SctO2 was significantly correlated with diastolic blood pressure, retinal venous oxygen saturation and retinal venous diameter (R 2 =0.60, P < 0.001). The measured SctO2 (72.2 ± 3.5%, range 67.3–80.1) correlated well with estimated SctO2 (72.2 ± 2.6%, range 67.6–77.5) (r = 0.774, P < 0.001). Bland–Altman plots showed 95% agreement within ±6.8%. Conclusions In this pilot study, retinal oximetry showed promising as an estimate of cerebral tissue oxygenation as measured by NIRS .